Active substances (INN): Dextrose (Glucose), sodium chloride

Composition: Dextrose in terms of anhydrous - 50 g;

Pharmacotherapeutic group: Saline solutions

Pharmacological properties

An agent for rehydration and detoxication which recovers well a bodily loss of liquid.

Dextrose  is a source of valuable, easily digestible nutrients which releases a significant amount of energy needed for vital activity of the organism when burns in tissues.

Sodium and chlorine ions are the most important inorganic components of extracellular liquid, controlling bodily distribution of water, regulating the acid-base balance, maintaining necessary osmotic pressure of blood plasma and extracellular liquid.

Dextrose  solution with sodium chloride for injections is valuable as a source of calories and electrolytes.

Indications to use

The drug is used for correction of liquid lost at dehydration of various genesis caused by vomiting, diarrhea, during a postoperative period, collapse, shock (as a component of various blood-substituting and anti-shock liquids), for maintenance of a blood plasma volume during and after surgery, for compensation of shortage in carbohydrates in the body, for disintoxicational infusion therapy, in hemorrhagic diatheses as well as for preparation of solutions of other drugs.

Administration and doses

Intravenously (i.v.) dropwise.

A solution should be preheated to 36-38°C before administration.

The drug is recommended to be administered slowly, through a needle of small diameter into large peripheral veins to minimize venous irritation. It is necessary to avoid formation of infiltrates caused by extravascular solution injection.

The dosage is prescribed by the doctor and depends on age, a body weight, a clinical state of the patient and results of laboratory tests.

Usually 300 to 1500 ml are used daily with the rate of about 80 drops/min maximum, 5 ml/p/kg to children.

The maximal daily dose for adults is 2000 ml.

The drug is used under the control of hematocrit and blood electrolyte concentration. The balance of the liquid injected and lost is measured every 6 hours.

Side effects

The drug may cause various reactions: febrile reaction (a headache, a rise in body temperature), infections in the site of injection, venous thrombosis or phlebitis extending from the injection site, extravasation and hypervolemia, nausea, vomiting, an abdominal pain, diarrhea, sweating, fever, tachycardia, arterial hypertension, renal function disorder, edemas, dyspnea, anxiety, weakness, twitching and muscle hypertonus. Administration of a large amount of the solution can result in chloride acidosis, overhydratation and increased bodily excretion of potassium.

When a reaction occurs, it is necessary to stop the injection, estimate the patient's state, take relevant therapeutic counter-measures and preserve the liquid remained for examination if need be.


Hypernatremia, an overhydratation state, hyperglycemia, diabetes mellitus, circulatory disturbances threatening with edema of lungs, the brain; chronic renal and heart failure, treatment with large doses of corticosteroids, hypersensibility to drug components.

Drug interactions

Combined utilization of the drug with glucocorticosteroids enhances hypernatremia. Therefore, it should be prescribed with care to patients receiving corticosteroids, corticotropin as well as patients prone to salt build-up.

Special warnings

As a Rehydrotonic solution contains sodium ions, it should be used with great care in patients with a congestive heart failure, especially in postoperative patients and older persons, in severe renal insufficiency, urinary tract obstruction, hypervolemia as well as in clinical states accompanied with sodium detention with edemas.

In continuous parenteral therapy it is necessary to monitor Dextrose  changes and the balance of liquid and electrolytes in blood by constant laboratory and clinical studies.

For children, especially newborns and premature neonates (whose renal function can be immature, or those with a limited ability of liquid excretion), dosages of an i.v. solution and the rate of drug infusion should be chosen with care due to an increased risk of development of hyperglycemia/hypoglycemia, serum hyperosmolarity and a possibility of hemorrhage. Constant monitoring of serum Dextrose  concentration, liquid consumption, diuresis and serum electrolytes is required. Even small amounts of liquids can affect water-salt balance in newborns and very small children.

The drug contains Dextrose ; therefore, caution should be used when it is given to patients with obvious or subclinical diabetes mellitus, or carbohydrate intolerance of any genesis.

To reduce a risk of possible incompatibilities resulting from mixing of Rehydrotonic with solutions of other drugs to minimum, the mixtures should be checked up visually for presence of turbidity or a deposit right after mixing, before administration as well as periodically during administration.

It is necessary to carry out permanently a clinical estimation and carried out periodically laboratory tests to track alteration of the liquid balance, concentration of electrolytes and acid-base balance during a continuous parenteral therapy, and if needed, on the patient's state.

No studies on utilization of the drug in pregnancy and lactation were undertaken. The drug should be prescribed to pregnant women only in case of emergency. It is necessary to follow up periodically the balance of liquid, Dextrose  and concentration of electrolytes as well as the acid-base balance of the mother and fetus.

It is necessary to control the amount of the liquid administered, urine excreted and serum electrolyte level.

The drug should be stored in a site inaccessible to children and not to be used after the expiry of its shelf life.


It is characterized by excess of liquid in the body (hypervolemia). If it occurs, stop injection immediately and prescribe relevant treatment. Administration of a hypertonic salt solution of sodium chloride, strong diuretics (in acute heart failure and edema of lungs) and correction of electrolyte balance is recommended.

Product form

Solution for infusions 100, 250 or 500 ml in vials.

Storage conditions

To be stored in a dry and protected from light place at temperature not more than 25°C.

Not to be frozen.


2 years.